By Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)
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Additional resources for Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
JAMA 262(18), 2551–6. Ewbank DC (1999) Deaths attributable to Alzheimer’s disease in the United States. Am J Public Health 89(1), 90–2. Fichter MM, Meller I, Schroppel H, Steinkirchner R (1995) Dementia and cognitive impairment in the oldest old in the community. Prevalence and comorbidity. Br J Psychiatry 166(5), 621–9. Fichter MM, Schroppel H, Meller I (1996) Incidence of dementia in a Munich community sample of the oldest old. Eur Arch Psychiatry Clin Neurosci 246(6), 320–8. Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B (1997) Very old women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen Project, Stockholm.
2. Incidence of age-speciﬁc dementia (as log of incidence of age-deﬁned population per annum) plotted against age. , 1999) and the Canadian Study of Health and Aging (2000). , 1998); and Shanghai, China (E. , 1998). , 1990). Similar results were obtained in the large study carried out in Bordeaux. Incidence data are now available. , 2000). An evident explanation of the protective effect of education is that education increases cognitive reserve, thus delaying the onset of the clinical symptoms of dementia (Katzman and Kawas, 1999).
He has published evidence that two isoforms of FE65 are upregulated in relatively unaffected regions of the brain of patients with LOAD, and has emphasized the importance of such investigations as a means of detecting the earliest events in pathogenesis. Most of his other lines of research have also used genetics to further our understanding of the pathobiology of human aging. Examples include the elucidation of the dominant nature of replicatively senescent cells, the biochemical genetic basis of the Werner syndrome, the ﬁrst determinations of the rates of accumulation of somatic mutations in aging human epithelial cells, and the ﬁrst estimates of the number of human genes involved in speciﬁc aspects of the senescent phenotype, including adult-onset dementias.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics by Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)