Download e-book for kindle: Advances in Pharmacology and Chemotherapy Volume 19 by Silvio Garattini

By Silvio Garattini

ISBN-10: 0080581102

ISBN-13: 9780080581101

ISBN-10: 0120329190

ISBN-13: 9780120329199

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Extra info for Advances in Pharmacology and Chemotherapy Volume 19

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J . Meti. Clrrm. 23, 682-684. Levin, V. , and Kabra, P. (1974). Rep. 58, 787-792. Levin, V. A . , Kabra, P. , and Freeman-Dove, M. A. (1978a). Crrnrer C / i r t t i o r k r . Phcirt i l u ( , o / . 1, 233-242. Levin, V. , Hoffman. , and Weinkam, R. J . (1978b). Conrer Trecit. Rep. 62, 1305-1312. /. Levin. V. , Steams, J . , and Weinkam, R. J. J. P / r ~ r m i c o Exp. T/ier. 208, 1-6. Levin, V. , and Weinkam, R. J . (1981). Critiier Rrs. 41, 3475-3477. , and Barbiers, A. R . (1960). Aniibior. Annu.

Ring hydroxylated products are also formed in v i w in rats and man. \ -3hydroxy, 4%; trcrris -3-hydroxy, 23%; and trtrns-2-hydroxy, 8%. During this period, 96% of the CCNU was metabolized (Hilton and Walker, 25 CHLOROETHYLNITROSOUREA 1975b). In addition to ring hydroxylation, thioacetic acid has been identified as a major urinary product from [ l''C]chloroethyl-CCNU (Reed and May, 1975). Phenobarbital also altered the distribution of hydroxylated metabolites in i i \ * o . Two minutes after CCNU administration, cis -4hydroxy CCNU was the major metabolite, 62%, along with significant amounts ofturuT-3-hydroxy CCNU, 2 l V (Hilton and Walker, 1975).

J . P/i(rrtfi. S c i . 66, 1073-1078. Lawley, P. , and Shah, S. A. (1973). ftitrrtici. 7, 115-119. Lawley, P. , and Warren, W. (1975). -Bio/. fnrertrcr. 11, 55-59. Levin, V. A. (1980). J . Meti. Clrrm. 23, 682-684. Levin, V. , and Kabra, P. (1974). Rep. 58, 787-792. Levin, V. A . , Kabra, P. , and Freeman-Dove, M. A. (1978a). Crrnrer C / i r t t i o r k r . Phcirt i l u ( , o / . 1, 233-242. Levin, V. , Hoffman. , and Weinkam, R. J . (1978b). Conrer Trecit. Rep. 62, 1305-1312. /. Levin. V. , Steams, J .

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