Download e-book for iPad: Advances in Microbial Physiology, Vol. 10 by A.H. Rose (ed.), D.W. Tempest (ed.)

By A.H. Rose (ed.), D.W. Tempest (ed.)

ISBN-10: 0120277107

ISBN-13: 9780120277100

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Additional info for Advances in Microbial Physiology, Vol. 10

Sample text

Conditions preventing RNA synt,hesis also inhibited thymine-less death, which therefore appears to be associated with RNA synthesis. The idea that it might be caused by induction of a defective episome or a prophage, raised as a remote possibility by Smith and HanawaIt (1968), should now be reconsidered in light of the finding that many A . laidlawii cultures are infected with specific viruses. Smith and Hanawalt (1968) also examined the effect of inhibition of protein synthesis on DNA synthesis in A .

Coli 5 S RNA (Johnson and Horowitz, 1971). 4% less GC than E . , 1969) and, with A . laidlawii tRNA, the difference is a mere 2% (Feldman and Falter, 1971). The low GC content of the mycoplasma DNA accordingly seems to be reflected in the tRNA, but not to the same extent in all species. Perhaps the most intriguing issue is the presence or absence of modified or minor nucleosides. Among cellular RNA species, tRNA is unique in containing numerous modified nucleosides. On the whole one might expect that the less genetic information an organism has the lower the variety and amount of its modified nucleosides, since the enzymes required for this synthesis might be missing.

Perhaps the most intriguing issue is the presence or absence of modified or minor nucleosides. Among cellular RNA species, tRNA is unique in containing numerous modified nucleosides. On the whole one might expect that the less genetic information an organism has the lower the variety and amount of its modified nucleosides, since the enzymes required for this synthesis might be missing. The failure of Hall et al. (1 967) to detect modified nucleosides in RNA from M . pulmonis strain 880 was, therefore, not unexpected.

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Advances in Microbial Physiology, Vol. 10 by A.H. Rose (ed.), D.W. Tempest (ed.)


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